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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

K current

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (2) Autophagy (4) Bacterial (2) Calcium Channel (5) Calmodulin (1) CFTR (2) Chloride Channel (1) Cytochrome P450 (2) Endogenous Metabolite (1) ERK (1) GABA Receptor (1) Guanylate Cyclase (1) Histamine Receptor (1) Isotope-Labeled Compounds (1) NF-κB (1) Parasite (1) Potassium Channel (33) Sodium Channel (4) TNF Receptor (2) TRP Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (16) Endocrinology (1) Infection (2) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (17)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-75839

Dronedarone Hydrochloride	Potassium Channel Autophagy	Cardiovascular Disease
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na ⁺, K ⁺ and Ca ²⁺ currents.

HY-13764

Tetrandrine 5+ Cited Publications NSC-77037; d-Tetrandrine	Calcium Channel Potassium Channel Parasite	Inflammation/Immunology Cancer
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca ²⁺ current (ICa) and Ca ²⁺-activated K ⁺ current.

HY-B2179

Cloperastine fendizoate	Potassium Channel	Inflammation/Immunology
Cloperastine fendizoate inhibits the hERG K ⁺ currents in a concentration-dependent manner with an IC₅₀ value of 27 nM.

HY-B2133

Cloperastine hydrochloride

Cloperastine hydrochloride inhibits the hERG K ⁺ currents in a concentration-dependent manner with an IC₅₀ value of 27 nM .

Cloperastine hydrochloride
Cloperastine hydrochloride inhibits the hERG K ⁺ currents in a concentration-dependent manner with an IC₅₀ value of 27 nM .

HY-110162

QO 58	Potassium Channel	Neurological Disease
QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability .

HY-P0249A

Phe-Met-Arg-Phe amide trifluoroacetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K ⁺ current, with ED₅₀ of 23 nM in the peptidergic caudodorsal neurons.

HY-15125

(R)-(+)-Bay-K-8644

Calcium Channel Cardiovascular Disease

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba ²⁺ currents (I_Ba) (IC₅₀=975 nM).
HY-119211

LY 97241

Potassium Channel Neurological Disease

LY 97241 accelerates the apparent rate of inactivation of transient outward K current. LY 97241 is an antiarrhythmic drug .

(R)-(+)-Bay-K-8644	Calcium Channel	Cardiovascular Disease
(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba ²⁺ currents (I_Ba) (IC₅₀=975 nM).

LY 97241	Potassium Channel	Neurological Disease
LY 97241 accelerates the apparent rate of inactivation of transient outward K current. LY 97241 is an antiarrhythmic drug .

HY-108575

Chromanol 293B	Potassium Channel CFTR	Cardiovascular Disease
Chromanol 293B is a selective blocker of the *slow delayed rectifier K ⁺ current* (IKs) with IC₅₀ of 1-10 μM and a weak inhibitor of KATP channel*. Chromanol 293B also blocks the CFTR chloride current* with an IC₅₀ of 19 μM .

HY-15124

(S)-(-)-Bay-K-8644 4 Publications Verification	Calcium Channel	Cardiovascular Disease
(S)-(-)-Bay-K-8644 is an agonist of L-type Ca ²⁺ channel. (S)-(-)-Bay-K-8644 activates Ba ²⁺ currents (I_Ba) (EC₅₀=32 nM).

HY-P0249

Phe-Met-Arg-Phe, amide

Potassium Channel Neurological Disease

Phe-Met-Arg-Phe, amide dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons.
HY-117528

WAY-123398

Others Cardiovascular Disease

WAY-123398 is a class III antiarrhythmic agent. WAY-123398 is a selective blocker of the delayed rectifier K ⁺ current .

Phe-Met-Arg-Phe, amide	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe, amide dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons.

WAY-123398	Others	Cardiovascular Disease
WAY-123398 is a class III antiarrhythmic agent. WAY-123398 is a selective blocker of the delayed rectifier K ⁺ current .

HY-106855

Almokalant H 234/09	Potassium Channel	Cardiovascular Disease
Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K ⁺ current.

HY-131899

N-Bromoacetamide	Potassium Channel Sodium Channel	Others
N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation .

HY-P0249B

Phe-Met-Arg-Phe, amide acetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe, amide acetate dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons .

HY-13710

Dimethindene	Histamine Receptor Potassium Channel Endogenous Metabolite	Neurological Disease
Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K ⁺ currents .

HY-110015

(-)-Chromanol 293B	Others	Cardiovascular Disease
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K ⁺ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic .

HY-75839R

Dronedarone Hydrochloride (Standard)	Potassium Channel Autophagy	Cardiovascular Disease
Dronedarone (Hydrochloride) (Standard) is the analytical standard of Dronedarone (Hydrochloride). This product is intended for research and analytical applications. Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na ⁺, K ⁺ and Ca ²⁺ currents.

HY-W010950A

Flecainide hydrochloride	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide hydrochloride is a potent and orally active antiarrhythmic agent. Flecainide hydrochloride blocks the cardiac fast inward Na ⁺ current (INa) and the rapid component of the delayed rectifier K ⁺ current. Flecainide hydrochloride prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide hydrochloride has the potential for the research of fetal tachycardias .

HY-W010950

Flecainide	Potassium Channel Sodium Channel	Cardiovascular Disease
Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na ⁺ current (INa) and the rapid component of the delayed rectifier K ⁺ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias .

HY-B0387

Ibutilide fumarate U70226E	Potassium Channel	Cardiovascular Disease
Ibutilide (U70226E) fumarate, an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K ⁺ current (I_Kr) in AT-1 cells .

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Neurological Disease Inflammation/Immunology
N-Salicyloyltryptamine acts on voltage-dependent Na ⁺, Ca ²⁺, and K ⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K ⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect ^- .

HY-B0387A

Ibutilide U70226E free base	Potassium Channel	Cardiovascular Disease
Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K ⁺ current (I_Kr) in AT-1 cells .

HY-P5165

Maurotoxin	Potassium Channel	Inflammation/Immunology
Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K ⁺ current with an IC₅₀ of 2 nM .

HY-101436

Sematilide CK-1752
Sematilide (CK-1752) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K ⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent .

HY-101436A

Sematilide hydrochloride CK-1752 hydrochloride
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective I_Kr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K ⁺ current (IC₅₀=25 μM). Sematilide is a class III antiarrhythmic agent .

HY-P1426

AmmTX3	Potassium Channel	Inflammation/Immunology
AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of K_v4 channel. AmmTX3 inhibits the A-type K ⁺ current (K_i: 131 nM) .

HY-15643

LY 303511	TNF Receptor Potassium Channel	Cancer
LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K ⁺ currents (IC₅₀=64.6±9.1 μM) in MIN6 insulinoma cells.

HY-15643A

LY 303511 hydrochloride 2 Publications Verification	TNF Receptor Potassium Channel	Cancer
LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K ⁺ currents (IC₅₀=64.6±9.1 μM) in MIN6 insulinoma cells.

HY-P1426A

AmmTX3 TFA	Potassium Channel	Inflammation/Immunology
AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of K_v4 channel. AmmTX3 TFA inhibits the A-type K ⁺ current (K_i: 131 nM) .

HY-B0387R

Ibutilide fumarate (Standard) U70226E (Standard)	Potassium Channel	Cardiovascular Disease
Ibutilide (fumarate) (Standard) is the analytical standard of Ibutilide (fumarate). This product is intended for research and analytical applications. Ibutilide (U70226E) fumarate, an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K ⁺ current (I_Kr) in AT-1 cells .

HY-B0432

Propafenone SA-79	Sodium Channel Adrenergic Receptor Potassium Channel	Cardiovascular Disease Cancer
Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC₅₀=32 nM) . Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC₅₀ values of 4.9 μm and 8.6 μm, respectively . Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis .

HY-103474

Bicuculline methiodide (+)-Bicuculline methiodide; d-Bicuculline methiodide	GABA Receptor	Neurological Disease
Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca ²⁺ -activated K ⁺ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca ²⁺ -activated K ⁺ current .

HY-135809

A2764 dihydrochloride	Potassium Channel	Neurological Disease
A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K ⁺ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC₅₀=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception .

HY-W020468

Linopirdine 1 Publications Verification DuP 996	Potassium Channel TRP Channel	Neurological Disease
Linopirdine (DuP 996) is an orally active, selective *M-type K ⁺ current* (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a TRPV1** agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue .

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-101379A

8-Bromo-cGMP sodium 1 Publications Verification	Calcium Channel	Cardiovascular Disease Neurological Disease
8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca ²⁺ macroscopic currents and impairs insulin release stimulated with high K ⁺ . 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses .

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent CFTR Cl ^- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases ΔF508-CFTR Cl ^- current after adding Forskolin .

HY-17508

Clarithromycin Maximum Cited Publications 11 Publications Verification	Bacterial Cytochrome P450 Autophagy Antibiotic	Infection Cancer
Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca ²⁺-activated K ⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca ²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺), and does not affect the Ca ²⁺-activated K ⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively) .

HY-105118A

Zaldaride maleate CGS-9343B; KW 5617	Calmodulin	Neurological Disease Metabolic Disease Inflammation/Immunology
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM . Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na ⁺, Ca ²⁺ and K ⁺ currents in PC12 cells and inhibits nAChR .

HY-17508S1

Clarithromycin-d3	Isotope-Labeled Compounds	Others
Clarithromycin-d₃is the deuterium labeledClarithromycin(HY-17508) . Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

HY-17508R

Clarithromycin (Standard)	Bacterial Cytochrome P450 Autophagy Antibiotic	Infection Cancer
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

HY-103371

DCPIB 5 Publications Verification	Chloride Channel Potassium Channel	Neurological Disease
DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC₅₀s: 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (I_Cl,swell), with an IC₅₀ of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels .

HY-P3071

ShK toxin	Potassium Channel	Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

HY-16915

RPR-260243 1 Publications Verification	Potassium Channel	Cardiovascular Disease
RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC₅₀=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel . RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name

HY-L015

PI3K/Akt/mTOR Compound Library

568 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 568 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

HY-L101

Anti-Liver Cancer Compound Library

1816 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 1816 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P0249A

Phe-Met-Arg-Phe amide trifluoroacetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K ⁺ current, with ED₅₀ of 23 nM in the peptidergic caudodorsal neurons.

HY-P5921

Tityustoxin-Kα TsTx-Kα	Peptides	Neurological Disease
Tityustoxin-Kα (TsTx-Kα) is an inhibitor of potassium voltage-gated channels. Tityustoxin-Kα shows a dose-dependent block of the sustained outward current in cultured hippocampal neurons .

HY-P0249

Phe-Met-Arg-Phe, amide

Potassium Channel Neurological Disease

Phe-Met-Arg-Phe, amide dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons.

HY-P0249B

Phe-Met-Arg-Phe, amide acetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe, amide acetate dose dependently (ED₅₀=23 nM) activates a K ⁺ current in the peptidergic caudodorsal neurons .

HY-P5165

Maurotoxin	Potassium Channel	Inflammation/Immunology
Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K ⁺ current with an IC₅₀ of 2 nM .

HY-P1426

AmmTX3	Potassium Channel	Inflammation/Immunology
AmmTX3 is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is specific blocker of K_v4 channel. AmmTX3 inhibits the A-type K ⁺ current (K_i: 131 nM) .

HY-P1426A

AmmTX3 TFA	Potassium Channel	Inflammation/Immunology
AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of K_v4 channel. AmmTX3 TFA inhibits the A-type K ⁺ current (K_i: 131 nM) .

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P3071

ShK toxin	Potassium Channel	Inflammation/Immunology
ShK toxin blocks voltage-dependent potassium channel (K_v1.3 channel). ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus). ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13764

Tetrandrine 5+ Cited Publications NSC-77037; d-Tetrandrine	Stephania tetrandra S. Moore Alkaloids Structural Classification Classification of Application Fields Source classification Plants Menispermaceae Inflammation/Immunology Disease Research Fields Alkaloid Dimers	Calcium Channel Potassium Channel Parasite
Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca ²⁺ current (ICa) and Ca ²⁺-activated K ⁺ current.

HY-13710

Dimethindene	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Histamine Receptor Potassium Channel Endogenous Metabolite
Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K ⁺ currents .

Cat. No.	Product Name	Chemical Structure

HY-17508S1

Clarithromycin-d3

Clarithromycin-d₃is the deuterium labeledClarithromycin(HY-17508) . Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC₅₀ (K_i) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .

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K current

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